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Illustration for Dr. Issam Ben-Sahra, PhD

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Ligand-mediated PAI-1 inhibition in a mouse model of peritoneal carcinomatosis; Josephine Hendrikson, Ying Liu, Wai Har Ng, ..., Melissa Ching Ching Teo, Chin-Ann J. Ong, on behalf of the Singapore Peritoneal Oncology Study (SPOS) Group and Singapore

ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain-of-function; Devesh C Pant, Janani Parameswaran, Lu Rao, Isabel Loss, Ganesh Chilukuri, Rosanna Parlato, Liang Shi, Jonathan D Glass, Gary J Bassell, Philipp Koch, Rüstem Yilmaz, J

Drug-microenvironment perturbations reveal resistance mechanisms and prognostic subgroups in CLL; Peter-Martin Bruch, Holly A. R. Giles, Wolfgang Huber, Sascha Dietrich and colleagues

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Issam Ben Sahra Lab — Northwestern University. Control of SAM abundance and RNA methylation by mTORC1 signaling.

Margaret Goodell Lab — Baylor College of Medicine. Mutant NPM1 Maintains the Leukemic State through HOX Expression.

Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids; Jan Fischer, Eduardo Fernández Ortuño, Fabio Marsoner, Annasara Artioli, Jula Peters, Takashi Namba, Christina Eugster Oegema, Wieland B. Huttner, Juli

Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer; Lele Song, Xinyi Yao, Hangpeng Li, ..., Yuanyuan Li, Haitao Li, Liling Wan

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters; Ashari R Kannangara, Daniel M Poole, Colten M McEwan, Joshua C Youngs, Vajira K Weerasekara, Alex M Thornock, Misael, T Lazaro, Eranga R Balasoo

Genome-scale CRISPR screening in a single mouse liver; Heather R. Keys, Kristin A. Knouse

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Margaret Goodell Lab — Baylor College of Medicine. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.

Margaret Goodell Lab, Erez Lieberman Aiden Lab — Baylor College of Medicine, and Xiaotian Zhang Lab — VAI Van Andel Institute. Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity.

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TGS1 impacts snRNA 3′-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration; Lu Chen, Caitlin M Roake, Paolo Maccallini, Francesca Bavasso, Roozbeh Dehghannasiri, Pamela Santonicola

Benjamin Deneen Lab — Baylor College of Medicine.
Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities.